Integrating metabolic engineering and immunotherapy

Immune cells hold enormous potential to specifically target and kill cancer cells. Yet, tumors have evolved inactivate T evade the immune system. cell cytotoxicity is regulated by various stimulatory inhibitory signals in order balance inflammation with tolerance. Immunotherapy has found these represent unique targets potentiate a tumor context. Besides signals, cellular metabolism represents an additional crucial layer of activity. Notably, nutrients can maintain within metabolic hurdles their microenvironment. Therefore, therapy complementary approach conventional immunotherapy strategies improve patient outcomes. In this review, we discuss how integrate ultimately regulate ability operate Moreover, review key studies showing benefit targeting together those effectively dismantle growth.